核凋亡诱导因子蛋白1
规格：1尘驳/1尘濒
英文名： NAIF1
别名： NAIF1 protein; nuclear apoptosis inducing factor 1; CB12-327; 2310007O20Rik; 4933440H19Rik; bA379C10.2; C9orf90; DKFZP762G199; NAIF1; RP11-379C10.2; NAIF1_HUMAN.
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NAIF1 N-
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
核凋亡诱导因子蛋白1细胞定位：
产物介绍：background: NAIF protein 1 (nuclear apoptosis inducing factor 1; CB12-327; RP-379C10.2) belongs to the NAIF1 family. Apoptosis is a genetically determined cell suicidal pro gram that plays critical roles in many physiological and pathological processes. nuclear apoptosis-inducing factor 1 (NAIF1), overexpression of which induces apoptosis in cells. Human NAIF1 is located on chromosome 9q34.11 and encodes 327 amino acids with a homeodomain-like region and two nuclear localization signals at its N-terminal region. NAIF1 is conserved across diverse species, including human, mouse, crab-eating macaque, dog, chicken and frog, and shares no obvious homology to any known genes 核凋亡诱导因子蛋白1or proteins. Northern blot analysis revealed wide expression of NAIF1 mRNA throughout human tissues. NAIF1 was predominantly localized in the nucleus. Overexpression of NAIF1 inhibited cell growth and induced apoptosis. Furthermore, NAIF1 transfection caused both decreases in mitochondrial membrane potential and caspase-3 activation. In summary, NAIF1 is a nuclear protein that induces apoptosis when overexpressed. Function: Induces apoptosis. Subunit: Interacts with HARBI1. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed. Similarity: Belongs to the核凋亡诱导因子蛋白1 NAIF1 family. Gene ID: 203245 Database links: Entrez Gene: 510689 Cow Entrez Gene: 203245 Human Entrez Gene: 71254 Mouse Omim: 610673 Human SwissProt: A7MBH3 Cow SwissProt: Q9BE21 Cynomolgus Monkey SwissProt: Q69YI7 Human SwissProt: Q6PFD7 Mouse Unigene: 373606 Human Unigene: 102341 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. NAIF1 protein(CB12-327)是*新发现的大肠癌标志物他抑制NFκB，NFAT，AP-1活性，并诱导细胞调亡。
核凋亡诱导因子蛋白1产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：染色质和核信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid