脂联素受体2抗体
规格：1尘驳/1尘濒
英文名： Adiponectin receptor 2
别名： Adipo R2; Progestin and adipoQ receptor family member II; Adipor2; PAQR2; ADR2_HUMAN.
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Adiponec
交叉反应：Human, Mouse, Rat, Dog, Pig,
细胞定位：细胞膜
脂联素受体2抗体产物介绍：background: The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied 脂联素受体2抗体by OMIM, Mar 2008] Function: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. Subunit: May form homo and heteromultimers. Subcellular Location: Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles. Tissue Specificity: Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain,脂联素受体2抗体 heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung. Similarity: Belongs to the ADIPOR family. Gene ID: 79602 Database links: Entrez Gene: 79602 Human Entrez Gene: 68465 Mouse Entrez Gene: 404694 Pig Entrez Gene: 312670 Rat Omim: 607946 Human SwissProt: Q86V24 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 脂联素与受体结合后具有增强胰岛素敏感性，抗高血糖，抗动脉粥样硬化等生物学效应，任何增加或减少脂联素及其受体表达的方法都影响这些**的发生和发展。 脂联素受体(AdipoR1和AdipoR2)同属于PAQR家族，具有七次跨膜蛋白的特有结构.
脂联素受体2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 生长因子和** 细胞膜受体 糖尿病 ***病
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid