肿瘤转移抑制基因抗体
规格：1尘驳/1尘濒
英文名： Nm23
别名： nucleoside dIPhosphatase kinase A; AWD; AWD, drosophila, homolog of; GAAD; Granzyme A activated DNase; GZMA activated DNase; Metastasis inhibition factor nm23; NB; NBS; NDK A; NDP kinase A; KDKA; NDPK
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Nm23
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：细胞核 细胞浆
肿瘤转移抑制基因抗体产物介绍：background: This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and肿瘤转移抑制基因抗体 farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. Subunit: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with SET and PRUNE. Subcellular Location: Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA. Tissue Specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, 肿瘤转移抑制基因抗体skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. Similarity: Belongs to the NDK family. Gene ID: 4830 Database links: Entrez Gene: 4830 Human Entrez Gene: 18102 Mouse Entrez Gene: 191575 Rat Omim: 156490 Human SwissProt: P15531 Human SwissProt: P15532 Mouse SwissProt: Q05982 Rat Unigene: 463456 Human Unigene: 439702 Mouse Unigene: 6236 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. nm23是一种转移抑制基因，主要用于胃肠道癌、乳腺癌、肺癌的多种恶性肿瘤的研究。大多数研究结果表明，nm23阳性表达与肿瘤转移负相关，与病人的预后呈正相关，但也有人研究报道与转移或预后无相关性，说明其结论仍有争议。
肿瘤转移抑制基因抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid