翱6甲基鸟嘌呤顿狈础甲基转移酶抗体
规格：1尘驳/1尘濒
英文名： MGMT
别名： 6 O methylguanine DNA methyltransferase; Agat; AGT; AI267024; EC 2.1.1.63; Methylated DNA protein cysteine methyltransferase; Methylguanine DNA methyltransferase; MGC107020; MGMT: O-6 methylguanine DN
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MGMT C-t
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
翱6甲基鸟嘌呤顿狈础甲基转移酶抗体产物介绍：background: MGMT (O6 methylguanine DNA methyltransferase) is an enzyme that transfers methyl groups from O(6) methylguanine, and other methylated moities of DNA, to a cysteine residue in itself, thus repairing DNA damage caused by alkylation in a single step reaction. This is a suicide reaction as the enzyme is irreversibly inactivated. MGMT prevents mutagenesis and malignant transformation, and also provides resistance to chemotherapy with alkylating agents among cancer patients. Function: 翱6甲基鸟嘌呤顿狈础甲基转移酶抗体Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Subcellular Location: Nucleus. Similarity: Belongs to the MGMT family. Gene ID: 4255 Database links: UniProtKB/Swiss-Prot: P16455.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or 翱6甲基鸟嘌呤顿狈础甲基转移酶抗体diagnostic applications. O-6-methylguanine-DNA methyltransferase(MGMT)O-6-甲基鸟嘌呤-DNA-甲基转移酶:是广泛存在于**到哺乳动物机体中的一种独特DNA修复酶，MGMT是一种DNA修复酶，是突变和癌变的抑制因子。它对烷化剂导致的DNA损伤有修复作用。 MGMT是突变和癌基因的抑制因子。研究表明MGMT水平与恶性肿瘤的发生、进展、浸润、预后及**有密切关系。细胞中MGMT水平与其所能耐受的DNA损伤密切相关。一般来讲，低水平表达MGMT的肿瘤可以应用烷化剂****；反之则为耐药。在正常组织中，肝脏高表达；脑组织和骨髓低水平表达。
翱6甲基鸟嘌呤顿狈础甲基转移酶抗体产物应用：WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid