肝细胞生长因子激活抑制蛋白2抗体
规格：1尘驳/1尘濒
英文名： HGFA Inhibitor 2
别名： Bikunin, placental; DIAR3; HAI-2; HAI2; Hepatocyte growth factor activator inhibitor type 2; Kop; Kunitz type protease inhibitor 2; Kunitz-type protease inhibitor 2; Kunitz-type serine protease inhibi
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SPINT2/H
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig,
细胞定位：细胞膜
肝细胞生长因子激活抑制蛋白2抗体产物介绍：background: Tissue damage, such as hepatic and renal injury, initiates hepatocyte growth factor activator (HGFAC)-mediated limited proteolytic activation of the inactive single-chain precursor form of HGF. Initially, HGFAC is produced as a precursor protein, which is activated by limited proteolysis and is neutralized by specific inhibitors known as HGF activator inhibitors, designated HAIs. HAIs belong to the Kunitz-type serine protease inhibitor family. HAIs target HGF activator and are involved in the regulation of proteolytic activation of HGF in injured tissues. Human HAI-1 transcript is expressed in various human tissues, such as placenta, kidney, pancreas, prostate and small intestine, and fetal kidney and lung. It translates into a 478 amino acid protein. The human HAI-2 gene maps to 肝细胞生长因子激活抑制蛋白2抗体chromosome 19q13.1 and encodes a 252 amino acid protein, also designated human placental bikunin or kop (Kunitz domain containing protein over-expressed in pancreatic cancer). HAI-1 and HAI-2 are produced in membrane-associated forms, which are secreted as active, proteolytically truncated proteins. Function: Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea. DISEASE: Defects in SPINT2 are the cause of diarrhea type 3 (DIAR3) [MIM:270420]; also known as congenital sodium diarrhea (CSD). DIAR3 is a rare, inherited diarrhea of infancy. A diagnosis of DIAR3 is made on the findings of a life-threatening secretory diarrhea, severe metabolic acidosis, and hyponatremia secondary to extraordinarily high fecal losses of sodium, with low or normal excretion of urinary sodium, in the 肝细胞生长因子激活抑制蛋白2抗体absence of infectious, autoimmune, and endocrine causes. Similarity: Contains 2 BPTI/Kunitz inhibitor domains. Gene ID: 10653 Database links: Entrez Gene: 10653 Human Entrez Gene: 20733 Mouse Entrez Gene: 292770 Rat Omim: 605124 Human SwissProt: O43291 Human SwissProt: Q9WU03 Mouse Unigene: 31439 Human Unigene: 295230 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
肝细胞生长因子激活抑制蛋白2抗体研究领域：发育生物学 神经生物学 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid