骋蛋白偶联受体109础抗体
规格：1尘驳/1尘濒
英文名： GPR109A
别名： HM74A; G-protein coupled receptor 109A; GPR109A; HM74a; HM74b; NIACR1; Puma-g; PUMAG; Niacr1; Niacin receptor 1; Nicotinic acid receptor; G-protein coupled receptor 109; G-protein coupled receptor HM7
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GPR109A/
交叉反应：Human, Mouse, Rat, Cow, Rabbit,
细胞定位：细胞膜
骋蛋白偶联受体109础抗体产物介绍：background: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. Function: Acts as a high affinity receptor for 骋蛋白偶联受体109础抗体both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > 骋蛋白偶联受体109础抗体acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 338442 Database links: Entrez Gene: 338442 Human Omim: 609163 Human SwissProt: Q8TDS4 Human Unigene: 524812 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
骋蛋白偶联受体109础抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid