础狈1型锌指蛋白5抗体
规格：1尘驳/1尘濒
英文名： ZFAND5
别名： AN1-type zinc finger protein 5; ZA20D2; ZFAN5_HUMAN; Zfand5; ZFAND5A; zinc finger A20 domain containing 2; Zinc finger A20 domain containing protein 2; Zinc finger A20 domain-containing protein 2; zin
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ZFAND5
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞浆
础狈1型锌指蛋白5抗体产物介绍：background: Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Could be involved in regulating NF-kappa-B activation and apoptosis. Is a potent inhibitory factor for osteoclast differentiation. Involved in protein degradation via the ubiquitin-proteasome system and plays a critical role in muscle atrophy. May act by anchoring ubiquitinylated proteins to the proteasome, playing a critical role in protein degradation. Function: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. 础狈1型锌指蛋白5抗体Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. Subunit: Interacts with ubiquitin and polyubiquitinated proteins. Identified in a heterotrimeric complex with ubiquitin and SQSTM1, where ZFAND5 and SQSTM1 both interact with the same ubiquitin molecule (By similarity). Homooligomer and/or heterooligomer. Interacts (via A20-type domain) with IKBKG and RIPK1 and with TRAF6 (via AN1-type domain). Subcellular Location: Cytoplasm. Tissue Specificity: Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly础狈1型锌指蛋白5抗体 expressed or undetectable in brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level). Similarity: Contains 1 A20-type zinc finger. Contains 1 AN1-type zinc finger. Gene ID: 7763 Database links: Entrez Gene: 7763 Human Entrez Gene: 22682 Mouse Entrez Gene: 293960 Rat Omim: 604761 Human SwissProt: O76080 Human SwissProt: O88878 Mouse SwissProt: B5DF11 Rat Unigene: 406096 Human Unigene: 292405 Mouse Unigene: 379919 Mouse Unigene: 4050 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
础狈1型锌指蛋白5抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 信号转导 细胞凋亡 转录调节因子 细胞外基质 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid