Ⅰ型补体受体抗体
规格：1尘驳/1尘濒
英文名： CD35
别名： C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD 35; CD35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3b/4b) receptor 1 including Knops blood
分子量： 274kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CR1/CD35
交叉反应：贬耻尘补苍,
细胞定位：细胞膜
Ⅰ型补体受体抗体产物介绍：background: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression Ⅰ型补体受体抗体of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. Function: Mediates cellular binding of particles and immune complexes that have activated complement. Subunit: Monomer. Subcellular Location: Membrane; Single-pass typeⅠ型补体受体抗体 I membrane protein. Similarity: Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. Similarity : Belongs to the receptors of complement activation (RCA) family. Contains 30 Sushi (CCP/SCR) domains. Gene ID: 1378 Database links: Entrez Gene: 1378 Human Omim: 120620 Human SwissProt: P17927 Human Unigene: 334019 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD35广泛分布于红细胞、粒细胞、单核细胞、肥大细胞、滤泡树突状细胞、肾小球足突细胞、B细胞及部分CD4+T细胞表面.CD35抗原又称为CR1或者C3b/C4b R，是一种分子量160-250kDa的C3b/C4b补体结合跨膜蛋白，主要用于滤泡树突状细胞标记和滤泡树突状细胞瘤的诊断。
Ⅰ型补体受体抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 细胞膜受体 **细胞 t-**细胞 b-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid