层粘连蛋白β4抗体
规格：1尘驳/1尘濒
英文名： Laminin subunit beta-4/LAMB4
别名： LAMB4; Laminin beta-1-related protein; Laminin subunit beta-4; Laminin, beta 4; LAMB4_HUMAN; Laminin beta-1-related protein.
分子量： 191kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Laminin
交叉反应：贬耻尘补苍,
层粘连蛋白β4抗体细胞定位：细胞浆
产物介绍：background: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Function: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane. Post-translational modifications: Phosphorylation of the protein kinase-like domain is required for full activation by CNP. DISEASE: Acromesomelic dysplasia, 层粘连蛋白β4抗体Maroteaux type (AMDM) [MIM:602875]: An autosomal recessive acromesomelic chondrodysplasia. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbsand hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary 层粘连蛋白β4抗体fingers (knob-like fingers). AMDM is characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain. Contains 1 protein kinase domain. Gene ID: 22798 Database links: Entrez Gene: 22798 Human SwissProt: A4D0S4 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
层粘连蛋白β4抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid