细胞粘合素(固生蛋白)抗体
规格：1尘驳/1尘濒
英文名： Tenascin C
别名： Tn-C; Cytotactin; Glioma associated extracellular matrix antigen; GMEM; GP 150 225; Hexabrachion; HXB ; JI; Myotendinous antigen; Neuronectin; Tenascin C; TenascinC; TN; TN C; TNC; TENA_HUMAN.
分子量： 239kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Tn-C
交叉反应：Human, Mouse, Rat, Pig,
细胞定位：细胞外基质 分泌型蛋白
细胞粘合素(固生蛋白)抗体产物介绍：background: Tenascin, also known as hexabrachion and cytotactin, is an extracellular matrix protein with a spatially and temporally restricted tissue distribution. It is a hexameric, multidomain protein with disulfide linked subunits of 190 to 240 kD, originally characterized as 'myotendinous antigen.' In the embryo it is present in dense mesenchyme surrounding developing epithelia and in developing cartilage and bone. In the , tenascin remains present in tendons and myotendinous junctions in the perichondrium and periosteum, as well as in smooth muscle. Function: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during细胞粘合素(固生蛋白)抗体 development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Subunit: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. Subcellular Location: Secreted, extracellular space, extracellular matrix. Similarity: Belongs to the tenascin family. Contains 15 EGF-like domains. Contains 1 fibrinogen C-terminal domain. Contains 15 fibronectin type-III domains. Gene ID: 3371 Database links: Entrez Gene: 3371 Human Entrez Gene: 21923 Mouse Entrez Gene: 116640 Rat Omim: 187380 Human SwissProt: 细胞粘合素(固生蛋白)抗体P24821 Human SwissProt: Q80YX1 Mouse SwissProt: B2LYI9 Rat Unigene: 143250 Human Unigene: 454219 Mouse Unigene: 980 Mouse Unigene: 12723 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Tenascin-C(TN-C)是重要的细胞外基质(ECM)成分之一,在组织器官的发**育中发挥着极其重要的作用;其表达具有复杂的时空分布,并受多种因素(细胞因子、**等)调节.目前主要用于消化系统肿瘤方面的研究。
细胞粘合素(固生蛋白)抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid