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整合素β7抗体

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产物名称: 整合素β7抗体
产物型号:
产物展商: 单克隆抗体/多克隆抗体
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简单介绍

整合素β7抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。整合素β7抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产物质量,质量稳定,实验效果明显。


整合素β7抗体  的详细介绍

整合素β7抗体

规格:1尘驳/1尘濒

英文名: Integrin beta 7

别名: Gut homing receptor beta subunit; Integrin beta 7 subunit; Integrin beta-7; Integrin beta-P; Integrin, beta 7; ITB7; ITB7_HUMAN; Itgb7; Ly69; M290 IEL antigen.

分子量: 85kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:笔辞濒测肠濒辞苍补濒

亚型:滨驳骋

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human Integrin

交叉反应:Human, Mouse, Rat,

细胞定位:细胞膜

整合素β7抗体产物介绍:background: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin. Function: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion整合素β7抗体 molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin. Subunit: Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin 整合素β7抗体alpha-4/beta-7 interacts with MADCAM1, VCAM, fibronectin, and may also interact with HIV-1 gp120. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed in a variety of leukocyte lines. Similarity: Belongs to the integrin beta chain family. Contains 1 VWFA domain. Gene ID: 3695 Database links: Entrez Gene: 3695 Human Entrez Gene: 16421 Mouse Omim: 147559 Human SwissProt: P26010 Human SwissProt: P26011 Mouse Unigene: 654470 Human Unigene: 58 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 整合素α4β7为黏膜归巢受体,是一种新的人类**缺陷病毒1(HIV-1)受体—整合素α4β7(integrin α4β7)被发现,在HIV进入人体后此受体引导其至消化道。此HIV受体的发现也许可解释为什么消化道为HIV复制的主要场所,整合蛋白表达高低与肿瘤细胞生物学行为关系的研究受到重视。

整合素β7抗体产物应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  **学  信号转导  干细胞  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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