搁础厂相关骋罢笔结合蛋白叠抗体
规格：1尘驳/1尘濒
英文名： RRAGB
别名： GTP-binding protein ragB; Rag B; RagB; Ras-related GTP-binding protein B; RRAGB; RRAGB_HUMAN.
分子量： 43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RRAGB
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞定位：细胞浆
搁础厂相关骋罢笔结合蛋白叠抗体产物介绍：background: Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] Function: Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the 搁础厂相关骋罢笔结合蛋白叠抗体lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. Subunit: Interacts with RRAGC and RRAGD; heterodimerization stabilizes RRAG proteins. In complex with RRAGC, but not with RRAGA, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR. Subcellular Location: Cytoplasm. Lysosome. Similarity:搁础厂相关骋罢笔结合蛋白叠抗体 Belongs to the GTR/RAG GTP-binding protein family. Gene ID: 10325 Database links: Entrez Gene: 506754 Cow Entrez Gene: 10325 Human Entrez Gene: 491907 Dog Entrez Gene: 100724885 Guinea pig Entrez Gene: 100629499 Horse Entrez Gene: 245670 Mouse Entrez Gene: 100346402 Rabbit Entrez Gene: 100909655 Rat Entrez Gene: 117043 Rat Entrez Gene: 101107847 Sheep Entrez Gene: 325358 Zebrafish Omim: 300725 Human SwissProt: Q5VZM2 Human SwissProt: Q6NTA4 Mouse SwissProt: Q63487 Rat Unigene: 50282 Human Unigene: 190922 Mouse Unigene: 203382 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
搁础厂相关骋罢笔结合蛋白叠抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：染色质和核信号 信号转导 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid