尿激酶型纤溶酶原激活因子抗体
规格：1尘驳/1尘濒
英文名： Urokinase
别名： Urokinase; ATF; ATF uPA; PLAU; UPA; Plasminogen activator; Plasminogen activator urinary; Plasminogen activator urokinase; u PA; U plasminogen activator; UPA; URK; Urokinase plasminogen activator; Uro
分子量： 49kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PLAU C-t
交叉反应：Human, Mouse, Rat,
细胞定位：分泌型蛋白
尿激酶型纤溶酶原激活因子抗体产物介绍：background: Urokinase is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in the Urokinase gene may be associated with late onset Alzheimer disease and also with decreased affinity for fibrin binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg Val bond in plasminogen. The proprotein is cleaved at a Lys Ile bond by plasmin to form a two chain derivative in which a single disulfide bond connects the amino terminal A chain to the catalytically active, carboxy terminal B chain. This two chain derivative is also called 尿激酶型纤溶酶原激活因子抗体HMW uPA (high molecular weight uPA). HMW uPA can be further processed into LMW uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino terminal fragment. LMW uPA is proteolytically active but does not bind to the uPA receptor. Function: Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. Subcellular Location: Secreted. Tissue Specificity: Expressed in the prostate gland and prostate cancers. Post-translational modifications: Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding. Similarity: Belongs to the peptidase S1 family. Contains 1 EGF-like domain. Contains 1 kringle domain. Contains 尿激酶型纤溶酶原激活因子抗体1 peptidase S1 domain. Gene ID: 5328 Database links: Entrez Gene: 5328 Human Entrez Gene: 18792 Mouse Entrez Gene: 25619 Rat Omim: 191840 Human SwissProt: P00749 Human SwissProt: P06869 Mouse SwissProt: P29598 Rat Unigene: 77274 Human Unigene: 4183 Mouse Unigene: 6064 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 尿激酶型纤溶酶激活因子;是一种多效细胞因子，参与多种病理生理过程；uPA系统可通过调节纤溶酶的活性降解p淀粉样蛋白;是一种丝氨酸蛋白酶，将血浆酶原转化成血浆酶（纤维蛋白溶酶）。
尿激酶型纤溶酶原激活因子抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 激酶和磷酸酶 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid