神经胶质蛋白(肝癌相关基因2)抗体
规格：1尘驳/1尘濒
英文名： Gliomedin
别名： CANCER RELATED GENE LIVER 2; Cancer related gene-Liver 2; CLOM; collomin; Colm (gene name); COLM; Colmedin; CRG L2; FLJ23917; Gldn (gene name); UNC 112; GLDN_HUMAN.
分子量： 59kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Gliomedi
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞膜
神经胶质蛋白(肝癌相关基因2)抗体产物介绍：background: Gliomedin is a 551 amino acid protein encoded by the human gene GLDN. Gliomedin is thought to play a role in the formation of the nodes of Ranvier along myelinated axons. Accumulation of Na+ channels at the nodes of Ranvier is a prerequisite for saltatory conduction. In peripheral nerves, clustering of these channels along the axolemma is regulated by myelinating Schwann cells through an unknown mechanism. Gliomedin is a glial ligand for Neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier. Gliomedin is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment during development, where it aligns with the forming nodes. Gliomedin is a single-pass type II membrane神经胶质蛋白(肝癌相关基因2)抗体 protein localized to the nodes of Ranvier and is specifically expressed in spinal cord, brain, placenta and sciatic nerve. It is more abundant in peripheral than central nervous system. Function: Gliomedin is a member of the collagen superfamily, it is a glial ligand for neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier. Gliomedin provides a glial cue for the formation of peripheral nodes of Ranvier. Gliomedin is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment during development, where it aligns with the forming nodes of ranvier. Eliminating the expression of gliomedin or the addition of a soluble extracellular domain of neurofascin to myelinating cultures abolishes node formation. Gliomedin is expressed in the PNS nodes of ranvier, but not in the CNS nodes of ranvier. Gliomedin also displays high expression in murine and human hepatocellular carcinomas (HCC). 神经胶质蛋白(肝癌相关基因2)抗体Its restricted expression in normal tissues and unique early upregulation during tumor development make it an excellent candidate as a new clinical marker of HCC. Subunit: Interacts with NFASC/neurofascin and NRCAM. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Note=Localizes to the nodes of Ranvier. Tissue Specificity: Specifically expressed in spinal cord, brain, placenta and sciatic nerve. More abundant in peripheral than central nervous system. Similarity: Contains 2 collagen-like domains. Contains 1 olfactomedin-like domain. Gene ID: 342035 Database links: Entrez Gene: 342035 Human Entrez Gene: 235379 Mouse Entrez Gene: 315675 Rat Omim: 608603 Human SwissProt: Q6ZMI3 Human SwissProt: Q7Z359 Human SwissProt: Q80ZC5 Mouse SwissProt: Q8BMF8 Mouse SwissProt: Q80WL1 Rat Unigene: 526441 Human Unigene: 123549 Mouse Unigene: 38054 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经胶质蛋白(肝癌相关基因2)抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 细胞粘附分子 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid