肿瘤坏死因子诱导蛋白8样蛋白2/TNFα-IP 8L2抗体
规格：1尘驳/1尘濒
英文名： TNFAIP8L2
别名： Tumor necrosis factor alpha-induced protein 8-like protein 2; Inflammation factor protein 20; TIPE2; TIPE 2; TIPE-2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; TNFAIP8L2; TP8L
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TNFAIP8L
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
肿瘤坏死因子诱导蛋白8样蛋白2/TNFα-IP 8L2抗体产物介绍：background: TNF Alpha-IP 8L2 (tumor necrosis factor, alpha-induced protein 8-like 2), also known as TIPE2, is a 184 amino acid protein that shares 94% identity with its mouse counterpart and belongs to the TNFAIP8 family. Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin, TNF Alpha-IP 8L2 plays a role in maintaining immune homeostasis, specifically by acting as a negative regulator of both innate and adaptive immunity. In addition, TNF?IP 8L2 functions as a negative regulator of T-cell receptor function and is thought to promote Fas-induced apoptosis. The gene encoding TNF?IP 8L2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. 肿瘤坏死因子诱导蛋白8样蛋白2/TNFα-IP 8L2抗体Function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. Subunit: May interact with CASP8; however, such result is unclearsince PubMed:19079267 could not reproduce the interaction withCASP8. Tissue Specificity: Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin Similarity: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily. 肿瘤坏死因子诱导蛋白8样蛋白2/TNFα-IP 8L2抗体Database links: Entrez Gene: 79626 Human Entrez Gene: 69769 Mouse Entrez Gene: 100328663 Rabbit Entrez Gene: 310663 Rat Entrez Gene: 510652 Cow Omim: 612112 Human SwissProt: A9X192 Baboon SwissProt: Q3ZBK5 Cow SwissProt: Q6P589 Human SwissProt: Q9D8Y7 Mouse SwissProt: B7NZC7 Rabbit SwissProt: Q6AYJ8 Rat Unigene: 709522 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肿瘤坏死因子诱导蛋白8样蛋白2/TNFα-IP 8L2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞凋亡
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid