罢础狈颁1蛋白抗体
规格：1尘驳/1尘濒
英文名： TANC1
别名： ROLSB; Protein TANC1; Rolling pebbles homolog B; TANC; Tanc1; TANC1_HUMAN; Tetratricopeptide repeat ankyrin repeat and coiled coil containing 1; Tetratricopeptide repeat ankyrin repeat and coiled coil
分子量： 202kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TANC1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
罢础狈颁1蛋白抗体产物介绍：background: TANC (tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein), also known as TANC1, is a 1,861 amino acid postsynaptic cell membrane protein that contains eleven ANK repeats, three TPR repeats and belongs to the TANC family. Considered a scaffolding component in the postsynaptic density, TANC interacts with TNIK, SAPAP1, Alpha-internexin, CaMKII, NMDA 2 and GluR-1. It is also thought that TANC interacts directly with SAP 97, PSD-95 and Homer. Upon stimulation by Rap 2罢础狈颁1蛋白抗体, MINK1 and TNIK may phosphorylate TANC. The TANC gene encodes two alternatively spliced isoforms, contains approximately 264,025 bases and maps to human chromosome 2q24.2. Making up approximately 8% of the human genome, chromosome 2 consists of 237 million bases and encodes over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome. Function: May be a scaffold component in the postsynaptic density. Subunit: Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1. Interacts with TNIK. Interacts with MINK1. Subcellular Location: Cell junction,罢础狈颁1蛋白抗体synapse, postsynaptic cell membrane, postsynaptic density. Post-translational modifications: Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A. Similarity: Belongs to the TANC family. Contains 11 ANK repeats. Contains 3 TPR repeats. Gene ID: 85461 Database links: Entrez Gene: 85461 Human Omim: 611397 Human SwissProt: Q9C0D5 Human Unigene: 61590 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
罢础狈颁1蛋白抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 细胞粘附分子 细胞骨架
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid