卡尔曼综合症基因1抗体
规格：1尘驳/1尘濒
英文名： KAL1
别名： KAL; Adhesion molecule-like X-linked; ADMLX; Anosmin-1; HHA; KAL1; KALIG 1; KALIG1; Kallmann syndrome 1 sequence (anosmin 1); Kallmann syndrome interval gene 1; Kallmann syndrome protein; KALM; KALM_H
分子量： 74kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human AF-6/l A
交叉反应：Human, Rat, Chicken, Dog, Pig, Horse, Sheep,
细胞定位：细胞膜 细胞外基质 分泌型蛋白
卡尔曼综合症基因1抗体产物介绍：background: May be an adhesion-like molecule with anti-protease activity. Function: Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells. Subunit: Interacts with FGFR1; this interaction does not interfere with FGF2-binding to FGFR1. Binds heparin. Heparin may promote or interfere with KAL1-FGFR1-FGF2 complex formation depending on the sequential order of its binding to the various constituents. For instance, heparin-KAL1 interaction favors subsequent binding to pre-existing binary卡尔曼综合症基因1抗体 FGFR1-FGF2 complex, while heparin-FGF2 complex does not interact with KAL1-FGFR1. Subcellular Location: Cell membrane; Peripheral membrane protein. Secreted. Note=Proteolytic cleavage may release it from the cell surface into the extracellular space. Tissue Specificity: Expressed in the cerebellum (at protein level). Post-translational modifications: N-glycosylated. DISEASE: Defects in KAL1 are the cause of Kallmann syndrome type 1 (KAL1) [MIM:308700]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to卡尔曼综合症基因1抗体 the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous. Similarity: Contains 4 fibronectin type-III domains. Contains 1 WAP domain. Database links: UniProtKB/Swiss-Prot: P23352.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
卡尔曼综合症基因1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 细胞骨架 细胞外基质
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid