项韧带弹性蛋白抗体
规格：1尘驳/1尘濒
英文名： Elastin
别名： Elastin; ELN; SVAS; Tropoelastin; WBS; WS.ELN_BOVIN.
分子量： 80kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from bovine Elastin
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：细胞外基质 分泌型蛋白
项韧带弹性蛋白抗体产物介绍：background: Elastic fibers, which are comprised primarily of elastin, endow loose connective tissue with a resilience that compliments the tensile strength of collagenous fibers. Elastin is the main component of the extracellular matrix of arteries, and it performs a regulatory function during arterial development by controlling proliferation of smooth muscle and stabilizing arterial structure. Elastin is composed largely of glycine, proline, and other hydrophobic residues, and it contains multiple lysine-derived crosslinks, such as desmosines, which link individual polypeptide chains into a rubber-like network. During aging, the elasticity of connective tissue becomes reduced because of the cross-linking of collagenous fibers with elastin. Deficiencies of elastin are associated with multiple disorders, such as supravalvular aortic stenosis and Williams-Beuren syndrome. The human elastin gene maps to chromosome 7q11.23. Function: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arteria项韧带弹性蛋白抗体l structure by regulating proliferation and organization of vascular smooth muscle. Subunit: The polymeric elastin chains are cross-linked together into an extensible 3D network. Forms a ternary complex with BGN and MFAP2. Interacts with MFAP2 via divalent cations (calcium > magnesium > manganese) in a dose-dependent and saturating manner. Subcellular Location: Secreted, extracellular space, extracellular matrix. Note=Extracellular matrix of elastic fibers. Post-translational modifications: Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with 项韧带弹性蛋白抗体other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross-links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates. Similarity: Belongs to the elastin family. Database links: Entrez Gene: 2006 Human Entrez Gene: 25043 Rat Omim: 130160 Human SwissProt: P15502 Human SwissProt: P54320 Mouse SwissProt: Q99372 Rat Unigene: 647061 Human Unigene: 275320 Mouse Unigene: 404771 Mouse Unigene: 54384 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
项韧带弹性蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 细胞粘附分子 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid