轴突生长诱导因子3抗体
规格：1尘驳/1尘濒
英文名： NTN3
别名： NET3_HUMAN; Netrin-2-like protein; Netrin3; Netrin-3; Netrin 3; NTN2L; NTN3.
分子量： 59kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NTN3/Net
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
细胞定位：细胞外基质 分泌型蛋白
轴突生长诱导因子3抗体产物介绍：background: Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins as the cells are repelled, rather than attracted, by the netrin gradient. Neogenin serves as the primary guidance receptor for netrin-3. Netrin-2 and the corresponding mouse homolog netrin-3 are expressed primarily in the lower two-thirds of the spinal cord, and, like netrin-1, they can either attract or轴突生长诱导因子3抗体 repel commissural axons at a distance. Netrin-3 proteins are associated with the axon fibers projecting from motor neurons and from neurons within sympathetic and sensory ganglia, suggesting that netrin-3 may be involved in pathfinding and fasciculation of axon projection. Neogenin serves as the primary guidance receptor for netrin-3. During peripheral nerve development, high netrin-3 expression 轴突生长诱导因子3抗体has been detected in mesenchymal cells, sensory ganglia and muscles. In humans, the gene encoding for the netrin-3 protein is localized to chromosome 16p13.3. Function: Netrins control guidance of CNS commissural axons and peripheral motor axons. Subcellular Location: Secreted; extracellular space; extracellular matrix. Tissue Specificity: Spinal cord. Similarity: Contains 3 laminin EGF-like domains. Contains 1 laminin N-terminal domain. Contains 1 NTR domain. Database links: Entrez Gene: 4917 Human Omim: 602349 Human SwissProt: O00634 Human Unigene: 158336 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
轴突生长诱导因子3抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 细胞粘附分子 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid