耳聋、常染色体隐性遗传22抗体
规格：1尘驳/1尘濒
英文名： OTOA
别名： Cancer/testis antigen 108; CT108; Deafness, autosomal recessive 22; DFNB22; OTOA; OTOAN_HUMAN; Otoancorin.
分子量： 122kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human OTOA/DFN
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜 细胞外基质 分泌型蛋白
耳聋、常染色体隐性遗传22抗体产物介绍：background: Otoancorin, also known as OTOA, CT108 or DFNB22, is a 1,153 amino acid protein belonging to the stereocilin family. Expressed in the inner ear and restricted to the interface between the apical surface of sensory epithelia, otoancorin is suggested to act as an adhesion molecule. Otoancorin ensures the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in the gene encoding otoancorin leads to deafness autosomal recessive type 22 (DFNB22), which is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the耳聋、常染色体隐性遗传22抗体 brain or the area of the brain that receives sound information. Existing as three alternatively spliced isoforms, otoancorin is encoded by a gene located on human chromosome 16p12.2. Function: May act as an adhesion molecule. Subcellular Location: Apical cell membrane. Secreted > extracellular space > extracellular matrix. At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes. DISEASE: Defects in OTOA are the cause of deafness autosomal recessive type 22 (DFNB22) [MIM:607039]. DFNB22 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the耳聋、常染色体隐性遗传22抗体nerve pathways to the brain, or the area of the brain that receives sound information. Similarity: Belongs to the stereocilin family. Database links: Entrez Gene: 146183 Human Entrez Gene: 246190 Mouse Omim: 607038 Human SwissProt: Q7RTW8 Human SwissProt: Q8K561 Mouse Unigene: 408336 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
耳聋、常染色体隐性遗传22抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 细胞粘附分子 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid