细胞外基质底物反应蛋白2抗体
规格：1尘驳/1尘濒
英文名： SPON2
别名： M spondin; Mindin; SPON 2; Differentially expressed in cancerous and non-cancerous lung cells 1; DIL 1; DIL-1; DIL1; M spondin; Mindin; Spon2; SPON2_HUMAN; Spondin 2; Spondin-2.
分子量： 33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SPON2_HU
交叉反应：Human, Mouse, Rat, Chicken, Horse,
细胞定位：细胞外基质 分泌型蛋白
细胞外基质底物反应蛋白2抗体产物介绍：background: The Thrombospondin proteins, Thrombospondins 1-4 and Thrombospondin 5 (also designated COMP), compose a family of glycoproteins that are involved in cell-to-cell and cell-to-matrix signaling. These extracellular, cell-surface proteins form complexes of both homo- and heteromultimers. Spondin-2, or Mindin, is also designated DIL-1 for its differential expression in cancerous and non-cancerous lung cells. Full-length SPON2 cDNA encodes a 331 amino acid protein with a domain arrangement similar to zebrafish F-Spondin and Mindin-1/Mindin-2: an FS1 domain, an FS2 domain, a hydrophobic signal sequence in the N-terminus and a 细胞外基质底物反应蛋白2抗体Thrombospondin type I repeat. Immunoblot analysis demonstrates expression of dimers and oligomers in a concentration-dependent manner under nonreducing conditions. Function: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). Subunit: Monomer. Interacts with integrin. Subcellular Location: Secreted; extracellular space; extracellular matrix. Tissue Specificity: Expressed in normal lung tissue but not in lung carcinoma cell lines. Similarity: Contains 1 spondin domain. Contains 1 TSP type-1 domain.细胞外基质底物反应蛋白2抗体 Database links: Entrez Gene: 10417 Human Entrez Gene: 100689 Mouse Entrez Gene: 171569 Rat Omim: 605918 Human SwissProt: Q9BUD6 Human SwissProt: Q8BMS2 Mouse SwissProt: Q9WV75 Rat Unigene: 302963 Human Unigene: 635350 Human Unigene: 34694 Mouse Unigene: 6699 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞外基质底物反应蛋白2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 细胞粘附分子 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid