腱糖蛋白搁抗体
规格：1尘驳/1尘濒
英文名： Tenascin R
别名： Janusin; Restrictin; TenascinR; Tenascin-R; Tenascin R (restrictin, janusin); Tenascin-R; TENR_HUMAN; TN-R; Tnr; TNR; TENR; MGC149328.
分子量： 146kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TNR/Tena
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
细胞定位：细胞外基质 分泌型蛋白
腱糖蛋白搁抗体产物介绍：background: The Tenascin family of extracellular matrix proteins includes Tenascin (also designated cytotactin or Tenascin-C), Tenascin-R (also designated Restrictin or Janusin) and Tenascin-X. Tenascin proteins function as substrate-adhesion molecules (SAMs) and are involved in regulating numerous developmental processes, such as morphogenetic cell migration and organogenesis. The Tenascin family proteins arise from various splicing events in the region of coding for FNIII repeats. Tenascin and Tenascin-X are expressed in several tissues during embryogenesis, and in tissues undergoing active remodel-ing such as healing wounds and tumors. Tenascin-R (TN-R) is expressed on the surface of neurons and glial cells. Function: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2 (FAK)腱糖蛋白搁抗体 phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance. Subunit: Forms oligomers. Interacts with CNTN1, TNC, and FN1. Interacts with BCAN and ACAN in a calcium-dependent manner. Interacts with SCN2B, PTPRZ1, and CSPG3 (By similarity). Subcellular Location: 腱糖蛋白搁抗体Secreted; extracellular space; extracellular matrix. Tissue Specificity: Brain specific. Post-translational modifications: Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure (By similarity). O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan. Similarity: Belongs to the tenascin family. Contains 5 EGF-like domains. Contains 1 fibrinogen C-terminal domain. Contains 9 fibronectin type-III domains. Database links: Entrez Gene: 3371 Human Entrez Gene: 21923 Mouse Entrez Gene: 116640 Rat Omim: 187380 Human SwissProt: P24821 Human SwissProt: Q80YX1 Mouse SwissProt: B2LYI9 Rat Unigene: 143250 Human Unigene: 454219 Mouse Unigene: 980 Mouse Unigene: 12723 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
腱糖蛋白搁抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 神经生物学 信号转导 细胞粘附分子 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid