胰岛素样生长因子结合蛋白2抗体
规格：1尘驳/1尘濒
英文名： IGFBP2
别名： BP 2; BP2; IBP 2; IBP-2; IBP2; IBP2_HUMAN; IGF binding protein 2; IGF BP53; IGF-binding protein 2; IGFBP 2; IGFBP-2; IGFBP2; IGFBP53; Insulin like growth factor binding protein 2 36kDa; Insulin like g
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IGFBP2
交叉反应：Human, Mouse, Rat,
细胞定位：分泌型蛋白
胰岛素样生长因子结合蛋白2抗体产物介绍：background: IGFBP2 (insulin-like growth factor binding protein 2) is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of other cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness Function: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been胰岛素样生长因子结合蛋白2抗体 shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Subcellular Location: Secreted. Post-translational modifications: O-glycosylated. Similarity: Contains 1 IGFBP N-terminal domain. Contains 1 thyroglobulin type-1 domain. Gene ID: 3485 Database links: Entrez Gene: 3485 Human Entrez Gene: 16008 Mouse Entrez Gene: 397064 Pig Entrez Gene: 25662 Rat Omim: 146731 Human SwissProt: P13384 Cow SwissProt: P18065 Human SwissProt: P47877 胰岛素样生长因子结合蛋白2抗体Mouse SwissProt: Q91VK7 Mouse SwissProt: P12843 Rat Unigene: 438102 Human Unigene: 141936 Mouse Unigene: 6813 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 生长因子和**（ Growth Factor and Hormones） 胰岛素样生长因子结合蛋白-2(IGFBP-2)是IGF/IGFBP家族中的一个重要成员,在多种**尤其是肿瘤中其表达明显增高,可能通过调节胰岛素样生长因子(insulin-like growth factor,IGF)发挥作用，促进肿瘤的发**展。
胰岛素样生长因子结合蛋白2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 生长因子和** 糖尿病
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid