成骨相关转录因子抗体
规格：1尘驳/1尘濒
英文名： Osterix
别名： Osterix; MGC126598; Osx; Sp 7; Sp7; Sp7 transcription factor; Transcription factor Sp7; Zinc finger protein osterix; SP7_HUMAN.
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Osterix
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核
成骨相关转录因子抗体产物介绍：background: This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010] Function: Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). Subunit: Interacts with NO66; the interaction is direct and inhibits transcription activator activity. Subcellular Location: Nucleus. Tissue Specificity: Osteoblast/chondrocyte specific. DISEASE: Osteogenesis imperfecta 12 (OI12) [MIM:613849]: A form 成骨相关转录因子抗体of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI12 is an autosomal recessive form characterized by recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to 成骨相关转录因子抗体the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers. Gene ID: 121340 Database links: Entrez Gene: 121340 Human Entrez Gene: 170574 Mouse Entrez Gene: 300260 Rat Omim: 606633 Human SwissProt: Q8TDD2 Human SwissProt: Q5RM08 Mouse SwissProt: Q8VI67 Mouse SwissProt: Q6IMK1 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Osterix成骨相关转录因子是一种具有锌指基序结构域的转录因子，在体内的表达对成骨细胞具有特异性。该蛋白只在发育的骨组织中特异性表达，是成骨细胞分化和骨形成过程中所必需的转录因子。骨髓基质干细胞分化为表达典型的成骨性标志基因的成骨细胞需要OSX的调控。
成骨相关转录因子抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 信号转导 干细胞 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid