轴突蛋白4/少突胶质细胞抗体
规格：1尘驳/1尘濒
英文名： CASPR
别名： Neurexin4; caspr 1; Caspr; Caspr1; Cntnap 1; Cntnap1; CNTP 1; CNTP1; CNTP1_HUMAN; Contactin associated protein 1; Contactin-associated protein 1; MHDNIV; NCP 1; NCP1; Neurexin 4; Neurexin IV; Neurexin
分子量： 154kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CASPR/Ne
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞膜
轴突蛋白4/少突胶质细胞抗体产物介绍：background: Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and CASPR (neurexin IV). Neurexins I-III are expressed as ? and ∫ isoforms. The ? isoforms are made of three cassettes, which contain two LNS (laminin A, neurexins, sex hormone-binding)-domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. The ? isoforms bind to neurexophilins at the second LNS site, and to the excitatory neurotoxin ?-latrotoxin. The ∫ isoforms have only one LNS-domain, bind to neuroligins and play a role in the formation and remodeling of synapses. CASPR (for contactin-associated protein 1, also designated paranodin in mouse), contains an extracellular domain similar to the othe轴突蛋白4/少突胶质细胞抗体r three neurexins, and binds to the surface glycoprotein contactin. CASPR and the closely related CASPR2, a mammalian homolog of Drosophila neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. Specifically, CASPR exists at the paranodal junctions, while CASPR2 co-localizes with Shaker-like K+ channels in the juxtaparanodal region. CASPR may play a role in the communication of glial cells and neurons during development. Function: Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role 轴突蛋白4/少突胶质细胞抗体in the signaling between axons and myelinating glial cells. Subunit: Interacts with contactin in cis form. Subcellular Location: Membrane. Tissue Specificity: Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis. Similarity: Belongs to the neurexin family. Database links: Entrez Gene: 8506 Human Entrez Gene: 53321 Mouse Entrez Gene: 84008 Rat Omim: 602346 Human SwissProt: P78357 Human SwissProt: O54991 Mouse SwissProt: P97846 Rat Unigene: 408730 Human Unigene: 474527 Mouse Unigene: 88654 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
轴突蛋白4/少突胶质细胞抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid