磷脂酰基醇蛋白聚糖-3抗体
规格：1尘驳/1尘濒
英文名： glypican 3
别名： glypican 3; glypican3; glypican-3; GPC3; Intestinal protein OCI-5; GTR2-2; MXR7.Intestinal protein OCI-5.
分子量： 65kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human glypican
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜 细胞外基质 分泌型蛋白
磷脂酰基醇蛋白聚糖-3抗体产物介绍：background: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome. (Also known as glypican 3; Intestinal protein OCI-5; GTR2-2; MXR7; Glypican-3 precursor). Function: Cell surface proteoglycan that bears 磷脂酰基醇蛋白聚糖-3抗体heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. Subcellular Location: Cell membrane and Secreted, extracellular space. Tissue Specificity: Highly expressed in lung, liver and kidney. DISEASE: Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1) [MIM:312870]; also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) 磷脂酰基醇蛋白聚糖-3抗体with visceral and skeletal anomalies. Similarity: Belongs to the glypican family. Gene ID: 2719 Database links: Entrez Gene: 2719 Human Entrez Gene: 14734 Mouse Entrez Gene: 25236 Rat Omim: 300037 Human SwissProt: P51654 Human SwissProt: Q8CFZ4 Mouse SwissProt: P13265 Rat Unigene: 644108 Human Unigene: 22515 Mouse Unigene: 9717 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GPC-3磷脂酰基醇蛋白聚糖-3是一种硫酸类肝素蛋白多糖，GPC-3在不同的组织中具有不同的生物学功能，甚至起着完全不同的作用，可能与肿瘤组织类型、发病机制等密切相关．GPC3在绝大多数HCC(肝细胞癌)患者有表达。
磷脂酰基醇蛋白聚糖-3抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid