角质蛋白α抗体
规格：1尘驳/1尘濒
英文名： SPRR1a
别名： 19 kDa pancornulin; Cornifin A; Cornifin alpha; CornifinA; Small proline rich protein 1A; Small proline rich protein IA; spr; SPR IA; SPRK; SPRR 1a; SPRR1A protein; SPR1A_HUMAN.
分子量： 10kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SPRR1a/C
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：细胞浆
角质蛋白α抗体产物介绍：background: The small proline rich protein (SPRR) gene family encodes a conserved group of cornified envelope (CE) proteins that are part of the human epidermal differentiation complex (EDC). The formation of the cornified envelope during the late stages of epidermal differentiation is essential for epidermal barrier function and protects the body against environmental attack and water loss. Additionally, the expression of SPRR proteins is linked to keratinocyte terminal differentiation. The SPRR gene family, namely comprises three subclasses of genes, SPRR1 (which contains two members), SPRR2 (which contains eight members) and SPRR3 (which contains one member).角质蛋白α抗体SPRR1 is found predominantly in follicular epidermis and oral mucosa, SPRR2 is expressed coherently in follicular and interfollicular epidermis and SPRR3 is absent in epidermis and strongly expressed in internal squamous. Function: The ability of neurons to regenerate an axon after injury is determined by both the surrounding environment and factors intrinsic to the damaged neuron. Neuronal SPRR1A is likely a significant contributor to successful nerve regeneration. The small proline-rich repeat protein 1A (SPRR1A) is not detectable in uninjured neurons but is induced by >60-fold after peripheral axonal damage being localized to injured neurons and axons. SPRR1A is one of a group of epithelial differentiation genes, including 角质蛋白α抗体s100c and p21/waf, that are cocurrently induced in neurons by axotomy. Overexpressed SPRR1A colocalizes with F-actin in membrane ruffles and augments axonal outgrowth on a range of substrates. In axotomized sensory neurons, reduction of SPRR1A function restricts axonal outgrowth. Subcellular Location: Cytoplasmic Similarity: Belongs to the cornifin (SPRR) family. Database links: Entrez Gene: 6698 Human Omim: 182265 Human SwissProt: P35321 Human Unigene: 46320 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
角质蛋白α抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid