细胞粘附分子伴侣蛋白1抗体
规格：1尘驳/1尘濒
英文名： Sidekick 1
别名： FLJ31425; Protein sidekick-1; sdk1; SDK1_HUMAN; sidekick 1 antibody Sidekick homolog 1, cell adhesion molecule (chicken); sidekick1.
分子量： 242kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Sidekick
交叉反应：Human, Mouse, Rat, Pig, Horse, Sheep,
细胞定位：细胞膜
细胞粘附分子伴侣蛋白1抗体产物介绍：background: Cell adhesion molecules influence cell growth, differentiation, embryogenesis, immune response and cancer metastasis by networking information from the extracellular matrix to the cell. Sidekick-1 (SDK1) is a 2,213 amino acid single-pass membrane protein that functions as a cell adhesion molecule by guiding axonal terminals to specific synapses in developing neurons. Existing as three alternatively spliced isoforms, Sidekick-1 is expressed in retinal neurons and contains thirteen fibronectin type-III domains and six Ig-like C2-type (immunoglobulin-like) domains. Sidekick-1 expression is upregulated in glomeruli of patients with HIV-associated nephropathy细胞粘附分子伴侣蛋白1抗体, where it leads to podocyte dysfunction. The gene encoding Sidekick-1 maps to human chromosome 7p22.2 and murine chromosome 5 G2. Function: Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons. Dysregulation of this protein may play an important role in podocyte dysfunction in HIV-associated nephropathy. Subunit: Contains 13 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains. Subcellular Location: Membrane. Tissue Specificity: Up-regulated in glomeruli in HIV-associated 细胞粘附分子伴侣蛋白1抗体nephropathy. In diseased glomeruli, significantly overexpressed and the expression is no longer restricted to mesangial cells but includes podocytes and parietal epithelial cells. Similarity: Contains 13 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains. Database links: UniProtKB/Swiss-Prot: Q7Z5N4.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞粘附分子伴侣蛋白1抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学 细胞粘附分子 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid