钙粘附分子10抗体
规格：1尘驳/1尘濒
英文名： Cadherin 10
别名： cadherin10; cadherin-10; Cadherin 10 (T2 cadherin); Cadherin 10 type 2 (T2 cadherin); Cadherin 10 type 2; Cadherin10; T2 cadherin; CAD10_HUMAN.
分子量： 82kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Cadherin
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
钙粘附分子10抗体产物介绍：background: The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. T2-cadherin, also known as cadherin-10 or CDH10, is a 788 amino acid single-pass type I membrane protein that belongs to the cadherin family and contains five cadherin domains. Expressed predominately in brain, but also found in prostate and both and fetal kidney, T2-cadherin functions as a calcium-dependent cell adhesion protein that is thought to be involved in the maintenance of synaptic adhesions, axon outgrowth and guidance. Function: 钙粘附分子10抗体Cadherin 10 is a type II classical cadherin from the cadherin superfamily. These are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in 钙粘附分子10抗体brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Subcellular Location: Cell membrane; Single-pass type I membrane protein Tissue Specificity: Predominantly expressed in brain. Also found in and fetal kidney. Very low levels detected in prostate and fetal lung. Database links: UniProtKB/Swiss-Prot: Q9Y6N8.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钙粘附分子10抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 细胞粘附分子 细胞骨架 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid