腺苷单磷酸活化蛋白激酶β1抗体
规格：1尘驳/1尘濒
英文名： AMPKB1 + PRKAB2
别名： 5 AMP activated protein kinase subunit beta 1; AMPK; AMPK beta 1 chain; AMPKb; HAMPKb; PRKAB1; 5'-AMP-activated protein kinase subunit beta-1; AMP-activated protein kinase beta subunit; protein kinase
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human AMPK bet
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
细胞定位：
腺苷单磷酸活化蛋白激酶β1抗体产物介绍：background: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]. Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK),腺苷单磷酸活化蛋白激酶β1抗体 an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). Subunit: AMPK is a heterotrimer of an alpha catalytic subunit腺苷单磷酸活化蛋白激酶β1抗体 (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2. Tissue Specificity: Highly expressed in kidney, heart, white adipose tissue, lung and spleen. Post-translational modifications: Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. Similarity: Belongs to the 5'-AMP-activated protein kinase beta subunit family. Gene ID: 5564 Database links: Entrez Gene: 5564 Human Entrez Gene: 19079 Mouse Entrez Gene: 83803 Rat Omim: 602740 Human SwissProt: Q9Y478 Human SwissProt: Q9R078 Mouse SwissProt: P80386 Rat Unigene: 6061 Human Unigene: 726001 Human Unigene: 458152 Mouse Unigene: 3619 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. AMPKβ1(AMP-activated Protein Kinase beta-1)(腺苷单磷酸活化蛋白激酶β-1)是一种参与细胞适应能量危机的应激反应酶,AMPK不仅可以在细胞水平作为能量的感受器，还可以通过**和细胞因子，如瘦素、脂联素和ghrelin来参与调节机体的能量消耗和能量摄入.
腺苷单磷酸活化蛋白激酶β1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid