妊娠区带蛋白笔窜笔抗体
规格：1尘驳/1尘濒
英文名：
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Pregnanc
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
妊娠区带蛋白笔窜笔抗体细胞定位：分泌型蛋白
产物介绍：background: Pregnancy Zone protein is a 1,482 amino acid secreted protein that belongs to the protease inhibitor I39 family and exists as multiple alternatively spliced isoforms. Expressed predominately in plasma and in late-pregnancy sera, Pregnancy Zone protein functions as a disulfide-linked homotetramer that is able to trap and inhibit proteinases, thus playing a role in the regulation of protein splitting and small peptide formation. The gene encoding Pregnancy Zone protein maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure 妊娠区带蛋白笔窜笔抗体disorders. Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Subunit: Homotetramer, which consists of two pairs of disulfide-linked chains. Subcellular 妊娠区带蛋白笔窜笔抗体Location: Secreted. Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Gene ID: 5858 Database links: Entrez Gene: 5858 Human Omim: 176420 Human SwissProt: P20742 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
妊娠区带蛋白笔窜笔抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
别名： A1m antibody; C3 and PZP like alpha-2 macroglobulin domain containing protein 6; Complement component 3 and pregnancy zone protein like alpha 2 macroglobulin domain containing protein 6; CPAMD6; PZP;
分子量： 161kDa