神经干细胞搁狈础结合蛋白惭耻蝉补蝉丑颈1抗体
规格：1尘驳/1尘濒
英文名： Musashi 1
别名： Musashi 1 / Msi1; Msi 1; Msi1; Msi-1; MSI1H_HUMAN; Musashi homolog 1; Musashi-1; Musashi1; RNA binding protein Musashi homolog 1; RNA-binding protein Musashi homolog 1.
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Musashi
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
神经干细胞搁狈础结合蛋白惭耻蝉补蝉丑颈1抗体细胞定位：细胞核 细胞浆
产物介绍：background: Musashi1 (Msi1) is an RNA-binding protein expressed in neural progenitor cells and neural stem cells. Msi1 is the mammalian homolog of Drosophila Musashi. The gene encoding human Msi1 encodes a 362 amino acid protein. In murine embryonic neural progenitor cells, Msi1 localizes to the cytoplasm and is downregulated during differentiation. Msi1 binds to NUMB, which encodes a membrane-associated antagonist of Notch signaling. Msi1 appears to function in the proliferation and maintenance of stem cell populations of the central nervous system. In addition to its usefulness as a marker for neural progenitor cells in normal human brains, Msi1 is also a marker for human 神经干细胞搁狈础结合蛋白惭耻蝉补蝉丑颈1抗体gliomas. In rats, Msi1 is expressed in Sertoli cells of the testis and granulosa cells of the ovary. Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Detected in fetal kidney, brain, liver and lung, and in brain and pancreas. Detected in hepatoma cell lines. Similarity: Belongs to the Musashi family. Contains 2 RRM (RNA recognition motif) domains. Gene ID: 4440 Database links: Entrez Gene: 4440 Human Entrez Gene: 17690 Mouse Entrez Gene:神经干细胞搁狈础结合蛋白惭耻蝉补蝉丑颈1抗体 259272 Rat Omim: 603328 Human SwissProt: O43347 Human SwissProt: Q61474 Mouse SwissProt: Q8K3P4 Rat Unigene: 158311 Human Unigene: 5077 Mouse Unigene: 162146 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Musashi1是一种进化保守的RNA结合蛋白，在维持干细胞状态、分化和肿瘤发生方面起着重要作用。Musashi1 选择性地表达在神经前体细胞上,包括神经干细胞上。在神经系统外，Musashi1还是肠干细胞的选择性标记。这些组织干细胞或未成熟细胞Musashi1的表达，表明Musashi1在转录后基因调节阶段维持这些细胞未分化状态起重要作用。Musashi1过度表达通过依赖RBP2Jk的旁路激活Notch1，而Notch信号途径功能为诱导哺乳动物神经干细胞自我更新。通过musashi1-P-小鼠培**细胞的Musashi蛋白产物反义去除研究,发现这些基因在维持神经干细胞未分化状态起着重要的作用。 Musashi抑制m-Numb转录的分子机制尚待进一步研究。Musashi1有可能除转录调控外还参与其他调控途径。另外，Musashi1还表达在一些脑肿瘤的特殊类型(这些肿瘤可能起源自非成熟脑细胞)，并且表达水平和肿瘤的恶性程度及增殖能力相关。
神经干细胞搁狈础结合蛋白惭耻蝉补蝉丑颈1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 干细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid