核受体蛋白狈搁2贰1抗体
规格：1尘驳/1尘濒
英文名： NR2E1
别名： NR2E1 / Tailless; Tailless; hTll; nr2e1; NR2E1_HUMAN; Nuclear receptor subfamily 2 group E member 1; Nuclear receptor TLX; Orphan nuclear receptor NR2E1; Protein tailless homolog; Tailless homolog; Tl
分子量： 43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NR2E1/Ta
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit,
细胞定位：细胞核
核受体蛋白狈搁2贰1抗体产物介绍：background: NR2 proteins are a large family of nuclear hormone receptor transcription factors. The proteins belonging to this family are characterized by discrete domains functioning in DNA and ligand binding. NR2E1 (nuclear receptor subfamily 2, group E, member 1), also known as TLX, is an essential component in the formation of synaptic plasticity and dendritic structure in retinal astrocytes. In addition, NR2E1 is a orphan receptor that binds DNA as part of the hormone response element (HRE), a transcription regulator for hormones. DNA-binding orphan receptors have the conserved sequence 5'-AAGGTCA-3', a motif that determines substrate binding specificity. NR2E1 is expressed in brain tissue, with highest levels in astrocytes, and is localized to the nucleus. Mutations in the gene that encodes NR2E1 may lead to retinal dystrophy,核受体蛋白狈搁2贰1抗体 a disorder characterized by a reduction in the thickness of the retina. Function: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required for brain development. May be involved in the regulation of retinal development. Subunit: Monomer (By similarity). Interacts with ATN1; the interaction represses the transcription Subcellular Location: Nucleus. Tissue Specificity: Brain specific.核受体蛋白狈搁2贰1抗体 Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus. Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. Gene ID: 7101 Database links: Entrez Gene: 7101 Human Entrez Gene: 396082 Chicken Entrez Gene: 21907 Mouse Entrez Gene: 684085 Rat Omim: 603849 Human SwissProt: Q91379 Chicken SwissProt: Q9Y466 Human SwissProt: Q3UXE8 Mouse SwissProt: Q64104 Mouse SwissProt: Q78ZM1 Mouse SwissProt: P70052 Xenopus laevis SwissProt: Q6DEH0 Zebrafish Unigene: 157688 Human Unigene: 287100 Mouse Unigene: 1067 Xenopus laevis Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核受体蛋白狈搁2贰1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 干细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid