核转录因子厂翱齿4抗体
规格：1尘驳/1尘濒
英文名： SOX4
别名： SOX4; SOX 4; SOX-4; Ecotropic viral integration site 16; EVI 16; EVI16; SRY (sex determining region Y) box 4; SRY box containing gene 4; SRY related HMG box gene 4.
分子量： 52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SOX4(54-
交叉反应：Human, Mouse, Rat, Chicken,
细胞定位：细胞核
核转录因子厂翱齿4抗体产物介绍：background: Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. Function: The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation 核转录因子厂翱齿4抗体of embryonic development and in the determination of cell fate. SOX4 shows a high degree of sequence homology with SOX11. Both are expressed in the CNS. SOX4 and SOX11 expression increase together in the developing CNS (with some exceptions: external granule layer of the cerebellum). SOX4 knock-out mice have been shown to die of a heart defect half way through gestation with no observable CNS phenotype核转录因子厂翱齿4抗体, although it has been proposed that SOX11 compensates for the absence of SOX4. Subunit: Interacts with UBE2I. Subcellular Location: Nuclear Tissue Specificity: Testis, brain, and heart. Similarity: Contains 1 HMG box DNA-binding domain. Database links: Entrez Gene: 395143 Chicken Entrez Gene: 768313 Cow Entrez Gene: 6659 Human Entrez Gene: 20677 Mouse Entrez Gene: 364712 Rat Entrez Gene: 336346 Zebrafish Omim: 184430 Human SwissProt: Q0VCF8 Cow SwissProt: Q06945 Human SwissProt: Q06831 Mouse Unigene: 643910 Human Unigene: 240627 Mouse Unigene: 455819 Mouse Unigene: 163667 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核转录因子厂翱齿4抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 干细胞 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid