笔鲍惭1蛋白抗体
规格：1尘驳/1尘濒
英文名： Pumilio 1
别名： HSPUM; KIAA0099; PUM 1; PUM L1; PUM1; PUM1_HUMAN; PUMH 1; PUMH; PUMH1; Pumilio homolog 1; Pumilio-1; Pumilio1; PUML 1; PUML1.
分子量： 126kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Pumilio
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞浆
笔鲍惭1蛋白抗体产物介绍：background: Pumilio 1, also known as PUM1, PUMH1 (Pumilio homolog 1), HSPUM, PUMH or PUML1, is a homolog of the Drosophila Pumilio protein and belongs to the PUF family. The PUF family is comprised of evolutionarily conserved proteins that contain a C-terminal RNA binding domain made up of eight highly conserved tandem repeats. PUF proteins function as sequence-specific RNA-binding proteins and bind NREs (nanos response elements) in the 3’-untranslated regions of target mRNAs. They play an important role mediating mRNA stabilization and repressing translation. Pumilio 1 is a typical PUF protein expressed in fetal tissues as well as stomach, kidney,笔鲍惭1蛋白抗体 intestine, muscle, brain and heart tissues. Pumilio 1 localizes to the cytoplasm and is believed to participate in cell fate, cell development, cell differentiation and maintenance of somatic stem cells. Function: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).笔鲍惭1蛋白抗体 Subunit: Binds in a sequence-specific manner to the 3'-UTR of some mRNAs. Subcellular Location: Cytoplasm (Probable). Tissue Specificity: Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested. Similarity: Contains 1 PUM-HD domain. Contains 8 pumilio repeats. Database links: UniProtKB/Swiss-Prot: Q14671.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
笔鲍惭1蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 干细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid