转录因子12抗体
规格：1尘驳/1尘濒
英文名： TCF12
别名： bHLHb20; Class B basic helix-loop-helix protein 20; DNA binding protein HTF4; DNA-binding protein HTF4; E box binding protein; E-box-binding protein; HEB; HTF4; HTF4_HUMAN; TCF-12; Tcf12; Transcriptio
分子量： 73kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TCF12
交叉反应：Human, Mouse, Rat, Horse, Rabbit, Zebrafish, Sheep,
细胞定位：细胞核
转录因子12抗体产物介绍：background: Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory seq转录因子12抗体uences of many muscle-specific terminal differentiation genes. Both homo- and hetero-oligomers of these proteins are able to distinguish very closely related E box proteins and are believed to play important roles in lineage specific gene expression. Function: Binds specifically to oligomers of E-box motifs. May play important roles during development of the nervous system as well as in other organ systems. 转录因子12抗体Subunit: Contains 1 basic helix-loop-helix (bHLH) domain. Subcellular Location: Nucleus. Tissue Specificity: Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line. Similarity: Contains 1 bHLH (basic helix-loop-helix) domain. Database links: Entrez Gene: 6938 Human Omim: 600480 Human SwissProt: Q99081 Human Unigene: 511504 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录因子12抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid