钙调蛋白激酶激酶α抗体颁补惭碍碍α
规格：1尘驳/1尘濒
英文名： CaMKK1
别名： CaMKKa; Calcium/calmodulin dependent protein kinase kinase alpha; CaM kinase kinase alpha; Ca2+/calmodulin-dependent protein kinase kinase alpha; Calcium/calmodulin dependent protein kinase kinase; Ca
分子量： 56kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CaMKK1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
钙调蛋白激酶激酶α抗体颁补惭碍碍α产物介绍：background: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. Function: Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. Subunit: Interacts with CAMK4 and calmodulin (By similarity).钙调蛋白激酶激酶α抗体颁补惭碍碍α Subcellular Location: Cytoplasm. Nucleus. Post-translational modifications: Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity). Similarity: Belongs to the protein kinase superfamily. 钙调蛋白激酶激酶α抗体颁补惭碍碍αSer/Thr protein kinase family. Contains 1 protein kinase domain. Database links: Entrez Gene: 84254 Human Entrez Gene: 55984 Mouse Omim: 611411 Human SwissProt: Q8N5S9 Human SwissProt: Q8VBY2 Mouse Unigene: 8417 Human Unigene: 9998 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钙调蛋白激酶激酶α抗体颁补惭碍碍α产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid