狈-乙基顺丁烯二酰亚胺敏感融合蛋白抗体
规格：1尘驳/1尘濒
英文名： NSF
别名： N ethylmaleimide sensitive factor; N ethylmaleimide sensitive factor; N ethylmaleimide sensitive factor like protein; N ethylmaleimide sensitive fusion protein; N ethylmaleimide sensitive fusion prote
分子量： 83kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NSF
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,
细胞定位：细胞浆
狈-乙基顺丁烯二酰亚胺敏感融合蛋白抗体产物介绍：background: Several protein-protein interactions are essential to membrane fusion during endocytosis. Membrane fusion requires interaction among SNARE1 proteins associated with both donor and acceptor membranes (1,2). Following membrane fusion, the α-SNAP cytoplasmic adapter protein binds to the SNARE complex. N-ethylmaleimide-sensitive factor (NSF), a hexameric ATPase, then associates with the α-SNAP/SNARE complex to mediate SNARE disassembly during membrane fusion (3,4). The ATPase activity of NSF induces a conformational change in the α-SNAP/SNARE complex that leads to its dissociation from the membrane, 狈-乙基顺丁烯二酰亚胺敏感融合蛋白抗体membrane fusion and eventual recycling of the SNARE complex for subsequent membrane fusion (3,4). Function: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Subunit: Homohexamer. Interacts with GABARAP and GABARAPL2. Interacts with GRIA2. Interacts with PLK2, leading to disrupt the interaction with GRIA2. Interacts with MUSK; may regulate MUSK endocytosis and activity (By similarity). Interacts with CDK16 狈-乙基顺丁烯二酰亚胺敏感融合蛋白抗体(By similarity). Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylation at Ser-569 interferes with homohexamerization (By similarity). Similarity: Belongs to the AAA ATPase family. Database links: Entrez Gene: 4905 Human Entrez Gene: 18195 Mouse Entrez Gene: 60355 Rat Omim: 601633 Human SwissProt: P46459 Human SwissProt: P46460 Mouse SwissProt: Q9QUL6 Rat Unigene: 431279 Human Unigene: 260117 Mouse Unigene: 13345 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
狈-乙基顺丁烯二酰亚胺敏感融合蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid