类固醇受体复合物蛋白贵碍叠笔5抗体
规格：1尘驳/1尘濒
英文名： FKBP51
别名： FKBP 5; FKBP 51; FKBP 54; FKBP-5; FKBP-51; FKBP5; FKBP5_HUMAN; FKBP54; HSP90 binding immunophilin; HSP90-binding immunophilin; P54 antibody Peptidyl prolyl cis trans isomerase; Peptidyl-prolyl cis-tra
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FKBP51
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
类固醇受体复合物蛋白贵碍叠笔5抗体产物介绍：background: The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin (1). Several related immunophilins, FKBP12, FKBP51 and FKBP52, are characterized as cytosolic FK506-binding proteins, and following ligand binding, they functionally inhibit the phosphatase activity of calcineurin (2,3). The ubiquitously expressed FKBP12 also associates with the cytoplasmic domain of the TGF?type I receptor, where it stabilizes the inactive conformation of the receptor and blocks the activation of the TGF?pathway (4). FKBP51 and FKBP52 are two highly related proteins (5,6). FKBP51 is predominantly expressed in T cells and is induced by glucocorticoids (5). FKBP51 mediates the 类固醇受体复合物蛋白贵碍叠笔5抗体effects of FK506 and rapamycin by inhibiting intracellular calcineurin activity, and by blocking T-cell activation and proliferation (7). FKBP52, known also as FKBP-59 or heat shock protein 56, is expressed in a variety of tissues and can also associate with the heat shock protein (hsp90) in mature steroid receptor complexes (6,8). Function: Interacts with functionally mature heterooligomeric progesterone 类固醇受体复合物蛋白贵碍叠笔5抗体receptor complexes along with HSP90 and TEBP. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Widely expressed, enriched in testis compared to other tissues. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 2 PPIase FKBP-type domains. Contains 3 TPR repeats. Database links: UniProtKB/Swiss-Prot: Q13451.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
类固醇受体复合物蛋白贵碍叠笔5抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：信号转导 细胞膜受体 t-**细胞
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid