早期发育调控蛋白2/贬顿颁2抗体
规格：1尘驳/1尘濒
英文名： PHC2
别名： HDC2; Early development regulatory protein 2; hPH2; early development regulator 2 (homolog of polyhomeotic 2); early development regulator 2 like; EDR2; MGC163502; mph2; PH2; PHC2; PHC2_HUMAN; polyhom
分子量： 91kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HDC2/PHC
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
早期发育调控蛋白2/贬顿颁2抗体产物介绍：background: In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including 早期发育调控蛋白2/贬顿颁2抗体Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Subunit: Component of a PRC1-like complex. Interacts with CBX4. Interacts with BMI1, PCGF2, PHC1 and RNF2. Interacts with CHTOP (By similarity). Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated upon DNA 早期发育调控蛋白2/贬顿颁2抗体damage, probably by ATM or ATR. Similarity: Contains 1 FCS-type zinc finger. Contains 1 SAM (sterile alpha motif) domain. Database links: Entrez Gene: 1912 Human Entrez Gene: 54383 Mouse Entrez Gene: 313038 Rat GenBank: NP_004418.2 Human Omim: 602979 Human SwissProt: Q8IXK0 Human SwissProt: Q9QWH1 Mouse Unigene: 524271 Human Unigene: 259103 Mouse Unigene: 2428 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
早期发育调控蛋白2/贬顿颁2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid