羟基类固醇(17β)脱氢酶4/17β-贬厂顿4抗体
规格：1尘驳/1尘濒
英文名： HSD17B4
别名： hydroxysteroid (17-beta) dehydrogenase 4; 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; 17 beta HSD 4; 17 beta HSD IV; 17 beta hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; 17-beta-hydro
分子量： 47/80kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HSD17B4
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, Guinea Pig, Zebrafish
羟基类固醇(17β)脱氢酶4/17β-贬厂顿4抗体细胞定位：细胞浆 线粒体
产物介绍：background: 17Beta-HSD4 (17Beta-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-Beta Estradiol dehydrogenase type IV. It belongs to the 17Beta-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17Beta-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol Beta-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17Beta-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17Beta-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal 羟基类固醇(17β)脱氢酶4/17β-贬厂顿4抗体migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period. Function: Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Subcellular Location: Peroxisome. Tissue Specificity: Present in many tissues with 羟基类固醇(17β)脱氢酶4/17β-贬厂顿4抗体highest concentrations in liver, heart, prostate and testis. DISEASE: Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD) [MIM:261515]. DBPD is a disorder of peroxisomal fatty acid beta-oxidation. Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. Contains 1 MaoC-like domain. Contains 1 SCP2 domain. Database links: UniProtKB/Swiss-Prot: P51659.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
羟基类固醇(17β)脱氢酶4/17β-贬厂顿4抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 神经生物学 信号转导 线粒体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid