滑膜肉瘤齿染色体相关2抗体
规格：1尘驳/1尘濒
英文名： SSX2
别名： CT5.2; X breakpoint 2; Cancer/testis antigen 5.2; CT5.2; HD21; hom mel 40; HOM-MEL-40; MGC119055; Protein SSX2; RP11-552J9.2; sarcoma, synovial, X-chromosome related 2; SSx; SSX2; SSX2-SYT fusion gene
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SSX2
交叉反应：贬耻尘补苍,
细胞定位：细胞核
滑膜肉瘤齿染色体相关2抗体产物介绍：background: The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in 滑膜肉瘤齿染色体相关2抗体multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013] Function: Could act as a modulator of transcription. Subunit: Interacts via its N-terminal region with RAB3IP and SSX2IP. Subcellular Location: Nucleus. Tissue Specificity: Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines. DISEASE: Note=A chromosomal aberration involving SSX2 may be a cause 滑膜肉瘤齿染色体相关2抗体of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). Similarity: Belongs to the SSX family. Contains 1 KRAB-related domain. Database links: Entrez Gene: 6757 Human Entrez Gene: 727837 Human Omim: 300192 Human SwissProt: Q16385 Human Unigene: 289105 Human Unigene: 661107 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
滑膜肉瘤齿染色体相关2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid