细胞质连接蛋白2抗体
规格：1尘驳/1尘濒
英文名： CLIP2
别名： CAP GLY domain containing linker protein 2; CAP-Gly domain-containing linker protein 2; CYLN2; CLIP 115; CLIP; CLIP-115; CLIP2; CLIP2_HUMAN; cytoplasmic linker 2; Cytoplasmic linker protein 115; Cytop
分子量： 116kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CYLN2
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：细胞浆
细胞质连接蛋白2抗体产物介绍：background: The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008] Function: Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operates in the control of 细胞质连接蛋白2抗体brain-specific organelle translocations. Subunit: Interacts with CLASP1 and CLASP2. Subcellular Location: Cytoplasm. Cytoplasm; cytoskeleton. Associated with the cytoskeleton. DISEASE: Note=CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular 细胞质连接蛋白2抗体and musculo-skeletal abnormalities observed in the disease. Similarity: Contains 2 CAP-Gly domains. Database links: Entrez Gene: 7461 Human Entrez Gene: 269713 Mouse Entrez Gene: 29264 Rat Omim: 603432 Human SwissProt: Q9UDT6 Human SwissProt: Q9Z0H8 Mouse SwissProt: O55156 Rat Unigene: 647018 Human Unigene: 255138 Mouse Unigene: 10893 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞质连接蛋白2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 细胞粘附分子 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid