液泡蛋白分选受体厂翱搁颁厂抗体
规格：1尘驳/1尘濒
英文名： SORCS1
别名： SorCS 1; SORCS; SORCS-1; SORCS receptor 1; Sortilin related VPS10 domain containing receptor 1; VPS10 domain containing receptor SorCS1; VPS10 domain receptor protein SORCS 1; VPS10 domain receptor pr
分子量： 127kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SORCS1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞膜
液泡蛋白分选受体厂翱搁颁厂抗体产物介绍：background: There are three sorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, the homologous SorCS1 and SorCS2 genes and the SorCS3 gene are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS1 is a type 1 receptor containing a VPS10P domain and a leucine-rich domain. Alternative splicing of human SorCS1 results in four isoforms with different cytoplasmic tails and differential expression in tissues. Human SorCS1 is detected in fetal and infant brain and in fetal retina. Alternative splicing of murine SorCS1 also 液泡蛋白分选受体厂翱搁颁厂抗体results in four isoforms. Murine isoform 1 is highly expressed in brain and at lower levels in heart, liver and kidney. It is detected in newborn mouse brain and in olfactory bulb and cerebral cortex. Murine isoform 2 is highly expressed in liver and at lower levels in heart, brain, kidney and testis. Function: SorCS1 belongs to the family of VPS10 domain-containing receptors (the name is derived from the yeast液泡蛋白分选受体厂翱搁颁厂抗体 vacuolar protein sorting protein-10, which is involved in sorting of carboxy-peptidase Y from the Golgi apparatus to the vacuole). SorCS1 immunoreactivity is widespread in a population of neurons throughout the brain. Two different types of cellular localization were observed. Most SorCS1 immunoreactive neurons exhibit a punctate cytoplasmic staining which extends into the dendrites, whilst occassionally SorCS1 neuronal immunoreactivity is associated with the plasma membrane. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Detected in fetal and infant brain and in fetal retina. Post-translational modifications: O-glycosylated. Similarity: Belongs to the VPS10-related sortilin family. SORCS subfamily. Contains 5 BNR repeats. Contains 1 PKD domain. Database links: UniProtKB/Swiss-Prot: Q8WY21.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
液泡蛋白分选受体厂翱搁颁厂抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞类型标志物 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid