颁础厂罢1蛋白抗体
规格：1尘驳/1尘濒
英文名： ERC2
别名： Cast; CAST1; CAZ-associated structural protein 1; Cmbp (gene name); Cytomatrix protein p110; ERC protein 2; KIAA0378; ERC2_HUMAN.
分子量： 110kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CAST1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
颁础厂罢1蛋白抗体产物介绍：background: ERCs (ERC1 and ERC2) also referred to as ELKS and CAST are related proteins which share an identical C-terminal sequence. They interact with the conserved RIM PDZ domain via an unusual PDZ binding motif. ERC2/CAST 1 is only expressed as a single RIM binding variant. All ERCs have been shown to interact with Rab6, a protein involved in membrane trafficking at the Golgi complex. The function of these proteins has not been determined yet. They may link Rab6 mediated non-neuronal membrane traffic at the Golgi complex to neuronal membrane traffic at the active zone executed via RIMs. Function: Thought to be involved in the organization of the 颁础厂罢1蛋白抗体cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. Subunit: Interacts with BSN, ERC1, PPFIA1, PPFIA2, PPFIA3 and PPFIA4. Interacts through its C-terminus with the PDZ domain of RIMS1. Part of a complex consisting of ERC2, RIMS1 and UNC13A. Subcellular Location: Cytoplasm. Cell junction; synapse.颁础厂罢1蛋白抗体 Cell junction; synapse: synaptosome. Cytoskeleton. Note: In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density. Database links: Entrez Gene: 26059 Human Entrez Gene: 238988 Mouse Entrez Gene: 259269 Rat SwissProt: O15083 Human SwissProt: Q6PH08 Mouse SwissProt: Q8K3M6 Rat Unigene: 476389 Human Unigene: 318004 Mouse Unigene: 213719 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
颁础厂罢1蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid