谷氨酸受体δ2/骋濒耻搁-δ2抗体
规格：1尘驳/1尘濒
英文名： GRID2IP
别名： Delphilin; delta 2 interacting protein 1; Grid Delta2; GluR-Delta 2 Glutamate receptor; GRD2I_HUMAN; grid2ip; ionotropic.
分子量： 132kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GRID2IP
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：细胞膜
产物介绍：background: Grid2ip is a postsynaptic scaffolding protein that contains one formin homology 2 (FH2) domain and two PDZ (postsynaptic 谷氨酸受体δ2/骋濒耻搁-δ2抗体density-95/discs-large/ZO-1) domains. Expressed in Purkinje cells of the cerebellum and localizing specifically to parallel fiber synapses, Grid2ip interacts with the C-terminus of GluR-Delta 2 and, via this interaction, links GluR-Delta 2 with various signaling molecules and the Actin cytoskeleton. GluR-Delta 2 is a glutamate receptor with an important role in motor learning, cerebellar wiring and synaptic plasticity. Due to alternative splicing events, three Grid2ip isoforms exist, namely L-delphilin, S-delphilin (or delphilin-Alpha) and delphilin-Beta.谷氨酸受体δ2/骋濒耻搁-δ2抗体 Each isoform exhibits individual expression patterns and protein interactions. Isoform 2, delphilin-Alpha, is palmytoylated, a modification that is essential for the enhanced expression of GluR-Delta 2 on the cell surface. This modification of delphilin-Alpha also mediates the accumulation of delphilin-Alpha in dendritic spines. Function: Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules. Subcellular Location: Cell junction > synapse > postsynaptic cell membrane.谷氨酸受体δ2/骋濒耻搁-δ2抗体 Similarity: Contains 1 FH2 (formin homology 2) domain. Contains 2 PDZ (DHR) domains. Gene ID: 392862 Database links: Entrez Gene: 392862 Human Omim: 610639 Human SwissProt: A4D2P6 Human Unigene: 512174 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
谷氨酸受体δ2/骋濒耻搁-δ2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 通道蛋白 细胞膜受体 细胞骨架 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid