神经细胞特异性钙结合蛋白抗体
规格：1尘驳/1尘濒
英文名： Hippocalcin
别名： BDR 2; BDR2; Calcium binding protein BDR 2; Calcium binding protein BDR2; Calcium-binding protein BDR-2; Hpca; HPCA_HUMAN; Neuron specific calcium binding protein hippocalcin; Neuron specific calcium-
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Hippocal
交叉反应：Human, Mouse, Rat, Chicken, Cow, Rabbit,
细胞定位：
神经细胞特异性钙结合蛋白抗体产物介绍：background: Hippocalcin is a neuron-specific calcium-binding protein found primarily in the plasma membrane of brain and retinal tissue, with increased expression observed in hippocampal pyramidal cells. Through its calcium-dependent signal regulation, hippocalcin can both inhibit rhodopsin kinase and increase phospholipase D2 expression. In order to regulate kinase and phospholipase activity, hippocalcin must bind to the plasma membrane where it can then bind two calcium ions for use in signal regulation. The hippocalcin protein is highly conserved in mouse, rat and human tissue and has a suggested role in neural plasticity and associative memory by c神经细胞特异性钙结合蛋白抗体ontributing to the survival of neurons during aging. The loss of hippocalcin expression is thought to contribute to age-related impairment of post-synaptic functions related to neuronal degradation. Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions. Tissue Specificity: Brain specific. Post-translational modifications: Myristoylation facilitates 神经细胞特异性钙结合蛋白抗体interaction with membranes. Similarity: Belongs to the recoverin family. Contains 4 EF-hand domains. Gene ID: 3208 Database links: Entrez Gene: 3208 Human Entrez Gene: 509772 Cow Entrez Gene: 15444 Mouse Entrez Gene: 29177 Rat Omim: 142622 Human SwissProt: Q4PL64 Cow SwissProt: P84074 Human SwissProt: P84075 Mouse SwissProt: P84076 Rat Unigene: 632391 Human Unigene: 384452 Mouse Unigene: 11019 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经细胞特异性钙结合蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid