层粘连相关多肽蛋白1抗体
规格：1尘驳/1尘濒
英文名： LAP1
别名： Densin 180; Densin; Densin-180; densin180; DKFZp686I1147; KIAA1365; Lamin associated polypeptide 1; LAP 1; Leucine rich repeat containing 7; Leucine rich repeat containing protein 7; Leucine-rich repe
分子量： 173kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Densin18
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
层粘连相关多肽蛋白1抗体产物介绍：background: Densin-180 is a synaptic transmembrane protein that is tightly associated with the postsynaptic density in CNS neurons and is postulated to function as a synaptic adhesion molecule. Densin-180 is a brain-specific momber of the O-sialoglycoprotein family which is highly concentrated at synapses along dendrites. The sequence of densin-180 contains 17 leucine-rich repeats, a sialomucin domain, an apparent transmembrane domain, and a PDZ (PSD-95, DIg, Z0-1) domain. The PDZ domain contributes to its binding to a-actinin. The intracellular portion of densin-180, CaMKIIa, interacts with a-actinin at distinct binding sites and, together, they form a ternary complex stabilized by multiple interactions. Function: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 层粘连相关多肽蛋白1抗体localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. Subunit: Interacts with CAMKII, CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2. Forms a complex with N-cadherin through CTNND2. Subcellular Location: Cytoplasm. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Tissue Specificity: Brain-specific. Isoform 3 is ubiquitously expressed. Similarity: Belongs to the LAP (LRR and PDZ)层粘连相关多肽蛋白1抗体 protein family. Contains 17 LRR (leucine-rich) repeats. Contains 1 PDZ (DHR) domain. Database links: Entrez Gene: 57554 Human Entrez Gene: 242274 Mouse Entrez Gene: 117284 Rat SwissProt: Q96NW7 Human SwissProt: Q80TE7 Mouse SwissProt: P70587 Rat Unigene: 479658 Human Unigene: 132162 Mouse Unigene: 89629 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
层粘连相关多肽蛋白1抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liqui