神经元突触膜胞外分泌调节蛋白1抗体
规格：1尘驳/1尘濒
英文名： ABCA4
别名： RIM1； ABCA4; CORD7; Rab-3-interacting molecule 1; Rab-3-interacting protein 2; RAB3 interacting protein 2; Rab3-interacting molecule 1; Rab3ip1; RAB3IP2; Regulating synaptic membrane exocytosis 1; Reg
分子量： 189kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RIM1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞膜
神经元突触膜胞外分泌调节蛋白1抗体产物介绍：background: The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]. Function: Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Subunit: Binds RAB3A, RAB3B and RAB3D that have been activated by GTP-binding. Interacts with RAB3C, RAB10, RAB26 AND RAB37. Binds UNC13A. Interacts with BZRAP1/RIMBP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts with ERC1 (By similarity). Binds SNAP25, SYT1 and CACNA1B. Interaction with SYT1 is enhanced by calcium ions. Interaction 神经元突触膜胞外分泌调节蛋白1抗体with SNAP25 is weaker in the presence of calcium ions. Subcellular Location: Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein (By similarity). Tissue Specificity: Detected in brain and retina. Post-translational modifications: Phosphorylated by BRSK1 (By similarity). DISEASE: Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7) [MIM:603649]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by神经元突触膜胞外分泌调节蛋白1抗体 loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Similarity: Contains 2 C2 domains. Contains 1 FYVE-type zinc finger. Contains 1 PDZ (DHR) domain. Contains 1 RabBD (Rab-binding) domain. Database links: Entrez Gene: 281584 Cow Entrez Gene: 24 Human Entrez Gene: 11304 Mouse Entrez Gene: 497268 Xenopus laevis Omim: 601691 Human SwissProt: O02698 Cow SwissProt: P78363 Human SwissProt: O35600 Mouse SwissProt: Q5F1L3 Xenopus laevis Unigene: 416707 Human Unigene: 3918 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经元突触膜胞外分泌调节蛋白1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞类型标志物 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid