突触泡蛋白2叠抗体
规格：1尘驳/1尘濒
英文名： SV2B
别名： Synaptic vesicle protein 2B; SV2B_HUMAN.
分子量： 77kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SV2B
交叉反应：Human, Mouse, Rat, Chicken, Rabbit,
细胞定位：细胞浆 细胞膜
突触泡蛋白2叠抗体产物介绍：background: In all vertebrates, SV2 proteins are abundant, hydrophobic, membrane glycoproteins that are expressed as two major isoforms, SV2A and SV2B, and one minor isoform, SV2C. SV2 proteins are differentially expressed in the brain and are present on all synaptic vesicles, independent of transmitter type. SV2A is abundantly expressed in the subcortex, specifically in the synaptic vesicles of all presynaptic nerve terminals, and also in most neuroendocrine secretory granules. SV2B displays a more restricted pattern of expression in that it is only present on a small subset of synapses in the hippocampus and cortex. SV2A and SV2B are funtionally redundant and are required 突触泡蛋白2叠抗体for maintaining normal brain function in vertebrates. SV2A and SV2B mediate synaptic transmission by regulating cytoplasmic Ca2+ levels in the nerve terminal during repetitive stimulation. Function: SV2s (Synaptic Vesicle protein 2) are integral membrane glycoproteins present in all synaptic vesicles. They have 12 transmembrane domains predicted by sequence analysis. There are three characterized isoforms, SV2A, SV2B and SV2C. While SV2A is expressed ubiquitously throughout the brain, SV2B has a more restricted distribution with varying degrees of coexpression with SV2A. SV2C is more closely related to SV2A but shows a very restricted expression pattern. Subunit: Interacts with SYT1 in a calcium-independent突触泡蛋白2叠抗体 manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 (By similarity). Subcellular Location: Cytoplasmic vesicle, secretory vesicle. Synaptic vesicle membrane; Multi-pass membrane protein. Post-translational modifications: N-glycosylated (By similarity). The N-terminal cytoplasmic domain is phosphorylated by CK1 (By similarity). Similarity: Belongs to the major facilitator superfamily. Database links: UniProtKB/Swiss-Prot: Q7L1I2.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
突触泡蛋白2叠抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid